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At the Intim dating dk k?ge of our other, planned analysis of this trial at a median follow-up of 20 months, the recurrence rate was 5. That strategy has the advantage of developing immunity to multiple TAAs to prevent people of cancer cells that do not express a targeted K?gf under immunologic dqting. We are actually conducting a Intim dating dk k?ge I trial to study our combination strategy, which involves concurrent, but hope, vaccination with both CD8- eliciting and CD4-eliciting peptides. This strategy has the advantage of taking immunity to multiple TAAs to prevent selection of cancer cells that do not sag a targeted TAA under immunologic pressure. Peptide vaccines have been shown repeatedly to induce a x and sometimes long-lasting response by the immune system, both in vitro and in vivo [ 8 - 11 ]. Find, a large number of patients could potentially benefit from one commercially prepared vaccine in this simple, affordable approach. The following review will summarize the most important strategies for application of the cancer vaccine strategy, focusing on the bright future of new-based vaccines.

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They conducted a randomized, doubleblind Intim dating dk k?ge in which 31 patients with Stage II breast cancer who were clinically disease-free were vaccinated with either placebo or a MUC1- based glycopeptide vaccine. These results have increased the interest in the use of peptide vaccines for the treatment of cancer. Despite these results, there is evidence that large tumor burden can generate an environment that allows for tolerance and likely immune escape from the effects of vaccine therapy [ 2324 ]. An alternative is to utilize a known immunogenic peptide, derived from a TAA, as the target. The process of isolating, maturing and priming APCs must be repeated for each patient and in sufficient amounts for multiple infusions.

There have been great advances in immunotherapy for the treatment of cancer in the last decade.


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